Recombinant enzymes
What are recombinant enzymes?
Recombinant enzymes are laboratory-produced proteins created through genetic engineering techniques. They are formulated with high purity to perform specific functions in aesthetic medicine, such as reducing signs of aging, imperfections, acne scarring, fibrosis, cellulite and localized fat.

What are recombinant enzymes used for?
Recombinant enzyme treatment is ideal for reducing facial wrinkles and fine lines, and for treating scars such as acne marks and stretch marks. It also helps improve cellulite, skin laxity and localized fat.
The most commonly used recombinant enzymes are:
Colagenasa GH PB220
For stimulating collagen production in the skin, helping achieve a more youthful appearance by tightening and improving its overall health. Its mechanism of action is based on the breakdown of triglycerides. It helps reduce excess volume and localized fat without damaging the tissue, and it promotes the elimination of surface sebum for better skin appearance and texture.
Hialuronidasa PB3000
It helps break down hyaluronic acid in the body. It is useful for correcting results from previous hyaluronic acid treatments that were not satisfactory. It also has a draining effect, helps reduce fluid retention, improves microcirculation and enhances skin appearance, helping patients achieve a more contoured figure.
Lipasa PB500
It helps eliminate localized fat. It reduces excess volume and localized fat without damaging the tissue. It also removes excess surface sebum to purify the skin and improve its appearance and texture.
Queratinasa PB333
Its action breaks down keratin. There are products that combine two or more recombinant enzymes to enhance their results in different aesthetic treatments. Thanks to targeted technology, it supports natural cell renewal and provides gentle yet effective exfoliation without causing irritation. It also increases permeability and improves the absorption of other active ingredients.
Benefits
- They act precisely on the targeted condition without affecting the surrounding skin.
- They help treat localized fat while also firming the skin and reducing cellulite.
- They improve lymphatic drainage.
- They are non invasive, require minimal recovery time and patients typically do not experience pain during the sessions.
- They are effective in rejuvenation treatments by improving skin texture, firmness and expression lines.
- They help improve acne scars, stretch marks and even keloids.
- Recombinant enzymes are effective for treating the double chin.
Duration
Each session generally lasts between 30 and 60 minutes. The number of sessions is determined by the specialist during the consultation and depends on the treatment goal.
Results are typically visible between 2 and 4 weeks after each session.
Application process
Recombinant enzymes can be combined with technologies such as microneedling or radiofrequency, and there are also topical options available.
The first step is cleansing the skin, followed by the selected technique to allow the recombinant enzymes to penetrate the tissue and begin working.
Expectations
Results can be maintained for 6 months to 1 year, depending on the treatment goals, the patient’s individual characteristics and healthy lifestyle habits.

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Frequently Asked Questions
What are recombinant enzymes?
Recombinant enzymes are laboratory-produced proteins created through genetic engineering techniques. There are three types most commonly used: collagenase, hyaluronidase and lipase, which are applied for facial rejuvenation, reduction of localized fat and scar improvement.
What are the benefits of recombinant enzymes?
Their benefits are extensive. They are used in facial rejuvenation to treat wrinkles and expression lines, double chin, and in body treatments to reduce localized fat, improve the appearance of cellulite and help diminish acne scars, stretch marks and burns, among others.
Is the treatment painful?
Patients who have undergone recombinant enzyme treatments typically report no pain. Only minor side effects may appear, such as swelling, redness or a burning sensation, which resolve quickly.
Is the use of recombinant enzymes safe?
Yes, patients respond very well to enzyme treatments and the results are targeted and effective.
Contraindications
The use of recombinant enzymes is not recommended for
- Immunocompromised patients, to avoid any risk of infection.
- Pregnant or breastfeeding women.
- Skin infections.
- Coagulation disorders.
- Individuals who have undergone cancer treatments within the past 6 months.
Regarding side effects, patients may experience redness, swelling or a burning sensation that usually subsides within a few hours after the procedure.
Recommendations
Avoid sun exposure for at least 24 hours after the session and use proper sun protection. Keep the skin well hydrated and avoid using products that may cause irritation. Avoid touching or manipulating the treated area.
Regarding side effects, patients may experience redness, swelling or a burning sensation that usually subsides within a few hours after the procedure.
Results can be maintained between 6 months and 1 year, depending on the treatment goals and the patient’s healthy lifestyle habits.
References
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